Experiment
・Purpose
I am doing research on synthesis of bioactive substances and novel synthesis methods. The phthalimidine skeleton is a skeleton that is common in bioactive compounds and has been studied from long ago. In my laboratory, my seniors succeeded in synthesizing phthalimidine derivatives by using catalyst in the past. To demonstrate the practicality of that method, I am synthesizing bioactive substances. In addition, during the consideration of the conditions, I found conditions under which another compound is generated. Fortunately, the product was a novel compound. Therefore, in order to synthesize the target compound using the compound, I am developing a new synthesis method.
・Describe
The catalyst used is called Lewis acid and plays a role of receiving electrons. This Lewis acid is often used in organic synthesis and is an important reagent for advancing the reaction. Of course, if an electron-rich atom is present in the substrate, the Lewis acid becomes easier to coordinate. If there are many heteroatoms, side reactions may occur.
Therefore, I think that it is necessary to advance the reaction while converting the substituent of the substrate. In addition, in the study of the synthesis method, I think that it is necessary to consider temperature, reaction time and reagents. The reaction can be activated by heating. The reactivity changes by converting the functional group into a good leaving group or devising the reagent so as to increase the nucleophilicity by using a base. Firstly, I need to find the optimum conditions for the reaction.
・Desired result
I would like to synthesize bioactive phthalimidine derivatives by the synthetic method found in our laboratory. I am trying to make the reaction proceed smoothly by introducing a substituent which is hard to coordinate with Lewis acid. If the yield of the target product is low, it is not a good reaction. Therefore, it is necessary to obtain a certain yield in each reaction. Even in the novel synthesis method, a good yield of the target compound is required. Furthermore, the reaction must proceed even with various substrates, and it is necessary to show practicality. Therefore, I should consider using a substrate with an electron withdrawing group or an electron donating group.
I am doing research on synthesis of bioactive substances and novel synthesis methods. The phthalimidine skeleton is a skeleton that is common in bioactive compounds and has been studied from long ago. In my laboratory, my seniors succeeded in synthesizing phthalimidine derivatives by using catalyst in the past. To demonstrate the practicality of that method, I am synthesizing bioactive substances. In addition, during the consideration of the conditions, I found conditions under which another compound is generated. Fortunately, the product was a novel compound. Therefore, in order to synthesize the target compound using the compound, I am developing a new synthesis method.
・Describe
The catalyst used is called Lewis acid and plays a role of receiving electrons. This Lewis acid is often used in organic synthesis and is an important reagent for advancing the reaction. Of course, if an electron-rich atom is present in the substrate, the Lewis acid becomes easier to coordinate. If there are many heteroatoms, side reactions may occur.
Therefore, I think that it is necessary to advance the reaction while converting the substituent of the substrate. In addition, in the study of the synthesis method, I think that it is necessary to consider temperature, reaction time and reagents. The reaction can be activated by heating. The reactivity changes by converting the functional group into a good leaving group or devising the reagent so as to increase the nucleophilicity by using a base. Firstly, I need to find the optimum conditions for the reaction.
・Desired result
I would like to synthesize bioactive phthalimidine derivatives by the synthetic method found in our laboratory. I am trying to make the reaction proceed smoothly by introducing a substituent which is hard to coordinate with Lewis acid. If the yield of the target product is low, it is not a good reaction. Therefore, it is necessary to obtain a certain yield in each reaction. Even in the novel synthesis method, a good yield of the target compound is required. Furthermore, the reaction must proceed even with various substrates, and it is necessary to show practicality. Therefore, I should consider using a substrate with an electron withdrawing group or an electron donating group.